![]() Tumour samples from 1316 (81%) patients were used for somatic molecular analyses 565 (43%) had KRAS mutations. ![]() The trial is registered, ISRCTN27286448.ฤก630 patients were randomly assigned to treatment groups (815 to standard therapy and 815 to addition of cetuximab). Further analyses with respect to NRAS, BRAF, and EGFR status were done. Here, we present the comparison of arm A and B, for which the primary outcome was overall survival in patients with KRAS wild-type tumours. The comparison of arms A and C is described in a companion paper. Randomisation was done centrally (via telephone) by the MRC Clinical Trials Unit using minimisation. The choice of fluoropyrimidine therapy (capecitabine or infused fluouroracil plus leucovorin) was decided before randomisation. In this randomised controlled trial, patients who were fit for but had not received previous chemotherapy for advanced colorectal cancer were randomly assigned to oxaliplatin and fluoropyrimidine chemotherapy (arm A), the same combination plus cetuximab (arm B), or intermittent chemotherapy (arm C). In the Medical Research Council (MRC) COIN trial, the epidermal growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard chemotherapy in first-line treatment of advanced colorectal cancer with the aim of assessing effect on overall survival. ![]() T S Maughan, M T Seymour, R H Wilson, R A Adams, H Wasan, A Madi, J Cassidy, M J Kennedy, E Hodgkinson, P Rogers, M Pope, A M Meade, R Kaplan, D Fisher, S L Kenny, J K Mitchell, L Nichols, L Harper, B Sydes, E Kay, L Thompson, L Clement, C Courtney, G Griffiths, C Murphy, M Parmar, C G Smith, R Harris, S Idziaszczyk, B Claes, D Lambrechts, J P Cheadle, B Jasani, S Storkel, R Adams, M James, J Northover, J Brown, M Aapro, R Stout, C Parker, M Mason, R Rudd, P W M Johnson, J Whelan, C Lowdell, R H Phillips, R Ahmad, P Riddle, A Creak, J Cassidy, A McDonald, A Waterston, N Mohammed, J White, H Yosef, A Hennessy, E M Bessell, V Potter, M Seymour, A Anthoney, A Melcher, R Cooper, D Sebag-Montefiore, P Ross, M Leslie, N Maisey, A Gaya, G Mikhaeel, J Summers, M Hill, R James, T S Maugham, A Brewster, T Crosby, S Mukherjee, N Iqbal, J Wadsley, D Furniss, S Pledge, J Hornbuckle, S Clenton, R Glynne-Jones, M Harrison, S Mawdsley, N Anyamene, R Hughes, D Propper, C Cottrill, D Smith, S Myint, N Ali, M Iqbal, P Clark, B Haylock, T Iveson, A Bateman, C Baughan, S Falk, K Hopkins, J Bridgewater, S Karp, C Topham, G Middleton, S Essapen, S Cummins, B Sizer, S Gollins, A Maraveyas, S Tahir, J Bridgewater, C Blesing, H Wasan, M Tighe, S Falk, R Ellis, J Dent, J K Joffe, S Shepherd, K Benstead, D Farrugia, P Mack, A Hamid, M Butt, R Roy, T Hickish, H Yosef, D Tsang, P Leonard, J Prejbisz, J Ledermann, J Bridgewater, T Hickish, R Osborne, A O'Callaghan, S R Muthuramalingam, F Adab, N J Wadd, J Van der Voet, D Wilson, J Wagstaff, C Askill, I Pedley, A Azzabi, E Marshall, R James, F Daniel, R Osborne, T J Iveson, D Jodrell, C McLean, S Clive, L Dawson, H A Philips, S Falk, R James, P Chakraborti, R Kulkarni, L M Samuel, G MacDonald, C Bradley, C Twelves, S Giridharan, F Adab, S Myint, S Gollins, N Stuart, C Bale, J Valle, M Saunders, G Wilson, A Weaver, A Jones, K McAdam, C Jephcott, S Cleator, A Webb, J Glaholm, R Hughes, P M Mulholland, N Steven, A Mayer, T Meyer, N Lo, G Cogill, L Toy, M Wilkins, C Wilson, C Palmer, I Geh, R Thomas, J Nicoll, P Chakraborti, A Azzabi, R Wilson, M Eatock, A Hartley, J Gildersleve, A Freebairn, G P Deutsch, A Webb, M Wilkins, F McKinna, D Cunningham, I Chau, S Susnerwala, M Wise, A Birtle, A Hamid, F J Lofts, J Kennedy, D Whillis, S Susnerwala, L T Tan, C Palmer, N Maisey, M Keane, C Macmillan, K Patel, D Farrugia, G Bertelli, V Vigneswaran, D Smith, R McDermott, S O'Reilly, V Hall, C Hamilton, A Dhadda, C Baughan, H Ford, M Moody, M Tomlinson, L Grogan, O Breathnach, R Soomal, J McCaffrey, C Rees, P J Atherton, S Beesley, W Dobrowsky, G Leonard, R Gupta, J Stewart, D Cunningham ![]()
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